Characteristics and distribution of endogenous RFamide-related peptide-1

P-222: Expression of RFamide-Related Peptide-3 and KiSS-1 mRNA in The Hypothalamus of Pregnant Rat

Background: There is no follicular development during pregnancy in the rat comparable to the changes of the estrous cycle. RFamide-related peptide-3 (RFRP-3) and kisspeptin were recognized as regulator of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in several species, including the rat. The aim of the present study was to evaluate the relative expression of RFRP...

Hypothalamic Expression of KiSS1 and RFamide-related Peptide-3 mRNAs during The Estrous Cycle of Rats

Endogenous Rfamide-related Peptides Alter Steady-state Desensitization of Asic1a

The acid sensing ion channels (ASICs) are proton-gated, voltage-insensitive cation channels expressed throughout the nervous system. ASIC1a plays a role in learning, pain, and fear related behaviors. In addition, activation of ASIC1a during prolonged acidosis following cerebral ischemia induces neuronal death. ASICs undergo steady-state desensitization, a characteristic that limits ASIC1a activ...

Increased Litter Size and Suckling Intensity Stimulate mRNA of RFamide-related Peptide in Rats

Background RFamide-related peptide-3 (RFRP-3) inhibits gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in rats. This study evaluates the effects of litter size and suckling intensity on RFRP mRNA expression in the dorsomedial hypothalamic nucleus (DMH) of rats. MaterialsAndMethods A total of 32 pregnant and 4 non-lactating ovariectomized (control group) Sprague-Dawl...

Expression of RFamide-Related Peptide-3 (RFRP-3) mRNA in Dorsomedial Hypothalamic Nucleus and KiSS-1 mRNA in Arcuate Nucleus of Rat during Pregnancy